RNK05047 (BRD4 CHAMP degrader)

RNK05047 is an investigational novel, small-molecule, chaperone-mediated protein degrader (CHAMP) targeting BRD4 (Bromodomain-Containing Protein 4) protein. RNK05047 accumulates in tumors relative to plasma and non-tumor tissues and induces degradation of BRD4 protein, but not related members of the Bromodomain and Extra-Terminal family (BET) protein family, BRD2 and BRD3, via the ubiquitin-proteasome system, thereby leading to downregulation of BRD4-regulated gene expression.

RNK08954 (KRAS G12D oral inhibitor)

RNK08954 is an investigational novel, oral small-molecule, non-covalently inhibits KRAS (Kirsten rat sarcoma) G12D, selectively binds to KRAS G12D over other mutations and wild type and achieves high exposure in tumors for the treatment of advanced solid tumors with a specific KRAS Mutation.